.

The structural connectome serves as the foundation for neural information signaling, playing a primary constraint on brain functionality. Yet, its influence on emergent dynamical properties is not fully understood. Generally, a key measure of a system’s structural impact on dynamical phenomena is its dimension. By tracking the temporal evolution of diffusive perturbations, we estimate a scale-dependent measure of dimension of empirical connectomes. At the local scale, it is highly heterogeneous and follows a gradient from sensory-motor to high-cognitive areas. At the global scale, it encapsulates mesoscale topological information related to the balance between segregation and integration. Furthermore, by comparing connectomes from stroke patients, we find that dimension captures the local effects of lesions and, at a global level, is linked to impaired critical patterns and decreased cognitive performance. Overall, the dimension of the connectome may serve as a powerful descriptor for bridging the gap between structure and function in the human brain.

The possibility that evolutionary forces -- together with a few fundamental factors such as thermodynamic constraints, specific computational features enabling information processing, and ecological processes -- might constrain the logic of living systems is tantalizing. However, it is often overlooked that any practical implementation of such a logic requires complementary circuitry that, in biological systems, happens through complex networks of genetic regulation, metabolic reactions, cellular signalling, communication, social and eusocial non-trivial organization. Here, we review and discuss how circuitries are not merely passive structures, but active agents of change that, by means of hierarchical and modular organization, are able to enhance and catalyze the evolution of evolvability. By analyzing the role of non-trivial topologies in major evolutionary transitions under the lens of statistical physics and nonlinear dynamics, we show that biological innovations are strictly related to circuitry and its deviation from trivial structures and (thermo)dynamic equilibria. We argue that sparse heterogeneous networks such as hierarchical modular, which are ubiquitously observed in nature, are favored in terms of the trade-off between energetic costs for redundancy, error-correction and mantainance. We identify three main features -- namely, interconnectivity, plasticity and interdependency -- pointing towards a unifying framework for modeling the phenomenology, discussing them in terms of dynamical systems theory, non-equilibrium thermodynamics and evolutionary dynamics. Within this unified picture, we also show that “slow” evolutionary dynamics is an emergent phenomenon governed by the replicator-mutator equation as the direct consequence of a constrained variational nonequilibrium process. Overall, this work highlights how dynamical systems theory and nonequilibrium thermodynamics provide powerful analytical techniques to study biological complexity.

The dismantling of complex networks due to targeted attacks has been extensively studied in network science. A method to assess the centrality of nodes to prioritize the targets of a network attack, namely Network Entanglement (NE), has been introduced in 2021, and a variation accounting for functional effects has been later introduced. The method is based on the concept of network density matrix, inspired by quantum information theory, which has been further developed in the last years.

The path towards the emergence of life in our biosphere involved several key events allowing for the persistence, reproduction and evolution of molecular systems. All these processes took place in a given environmental context and required both molecular diversity and the right non-equilibrium conditions to sustain and favour complex self-sustaining molecular networks capable of evolving by natural selection. Life is a process that departs from non-life in several ways and cannot be reduced to standard chemical reactions. Moreover, achieving higher levels of complexity required the emergence of novelties. How did that happen? Here, we review different case studies associated with the early origins of life in terms of phase transitions and bifurcations, using symmetry breaking and percolation as two central components. We discuss simple models that allow for understanding key steps regarding life origins, such as molecular chirality, the transition to the first replicators and cooperators, the problem of error thresholds and information loss and the potential for ‘order for free’ as the basis for the emergence of life.

A broad class of systems, including ecological, epidemiological, and sociological ones, are characterized by populations of individuals assigned to specific categories, e.g., a chemical species, an opinion, or an epidemic state, that are modeled as compartments. Because of interactions and intrinsic dynamics, the system units are allowed to change category, leading to concentrations varying over time with complex behavior, typical of reaction-diffusion systems. While compartmental modeling provides a powerful framework for studying the dynamics of such populations and describe the spatiotemporal evolution of a system, it mostly relies on deterministic mean-field descriptions to deal with systems with many degrees of freedom. Here, we propose a method to alleviate some of the limitations of compartmental models by capitalizing on tools originating from quantum physics to systematically reduce multidimensional systems to an effective one-dimensional representation. Using this reduced system, we are able not only to investigate the mean-field dynamics and their critical behavior, but we can additionally study stochastic representations that capture fundamental features of the system. We demonstrate the validity of our formalism by studying the critical behavior of models widely adopted to study epidemic, ecological, and economic systems.

The spatial spread of infectious diseases is ruled by two processes: the disease progression and human behavior, which comprises human contacts and human mobility. A standard modeling approach is to define an epidemiological model upon a metapopulation network under some restrictive assumptions, such as that all processes happen at the same time scale, dispersal is diffusive, and agents are indistinguishable with respect to age and behavioral features. Although several models relax at least one of those assumptions, providing new insights about an epidemic, rarely are they relaxed all at once. Here, we introduce a model whose equations explicitly contain two parameters that encode the ratios between the time scales of the recovery, contact, and mobility processes, while simultaneously accounting for the age structure of the agents, different mobility layers, and different social settings for contacts. Furthermore, to reflect more closely real-world scenarios, we consider two settings: a diffusion-based one in which agents disperse like particles to spread the epidemics, effectively changing the starting population size far from and at equilibrium, and a force-based one where spread happens without changing the population of patches far from equilibrium. For both spreading frameworks, we study the regimes under which they provide distinct results and the critical properties of the epidemic process, finding that the curve of the critical points, which separate increasing or decreasing trends in the number of infected individuals – as well as other macroscopic observables of interest such as the attack rate – in the space of the two scale parameters exhibits a critical point itself. Complementing spatially-oriented strategies, the proposed approaches can contribute to the design of effective non-pharmaceutical interventions by focusing on the mutual influence of temporal scales, dispersal dynamics, and human behavior. In particular, our study allows for an optimal tuning of mobility and contact restrictions based on the characteristics of the disease and its spatial distribution in the early phase of spreading..

Human-made infrastructures are complex systems continually exposed to events that threat their function, such as cascading failures, occurring when the flow of physical quantities is redistributed within the network as a consequence of localized disruptions. Nevertheless, the role played by exogenous catastrophic events and internal failures on the robustness of critical infrastructures is usually addressed independently, under simplifying assumptions and lacking a unified picture for realistic risk assessments. Here, we fill this gap by introducing the Operational-Affected-Dismantled (OAD) model that captures both local and nonlocal failure propagation mechanisms. The model combines reaction–diffusion processes for local spreading with a global field effect for long-range interactions, allowing us to quantitatively characterize the cascade dynamics in infrastructure networks. Moreover, we include information on external stressors to assess the robustness of empirical network infrastructures and build spatial risk maps. By using data from severe storms (2009–2016) and from earthquakes (2000–2023) as stressors of the North American power grid and the worldwide airline transportation system, respectively, we offer a quantitative way to rank events by their potential to trigger systemic effects. By analyzing the response of the European power grid to simulated severe storms, we find that it can show high levels of systemic risk. Uncertainty in global climate and the accelerating frequency of extreme events all over the globe call for novel strategies to quantify, adapt to and mitigate systemic risk. Our framework provides a suitable starting point to assess the robustness of empirical systems in realistic and what-if scenarios.

It has been argued that the historical nature of evolution makes it a highly path-dependent process. Under this view, the outcome of evolutionary dynamics could have resulted in organisms with different forms and functions. At the same time, there is ample evidence that convergence and constraints strongly limit the domain of the potential design principles that evolution can achieve. Are these limitations relevant in shaping the fabric of the possible? Here, we argue that fundamental constraints are associated with the logic of living matter. We illustrate this idea by considering the thermodynamic properties of living systems, the linear nature of molecular information, the cellular nature of the building blocks of life, multicellularity and development, the threshold nature of computations in cognitive systems, and the discrete nature of the architecture of ecosystems. In all these examples, we present available evidence and suggest potential avenues towards a well-defined theoretical formulation.

Complex networks are ubiquitous: a cell, the human brain, a group of people and the Internet are all examples of interconnected many-body systems characterized by macroscopic properties that cannot be trivially deduced from those of their microscopic constituents. Such systems are exposed to both internal, localized, failures and external disturbances or perturbations. Owing to their interconnected structure, complex systems might be severely degraded, to the point of disintegration or systemic dysfunction. Examples include cascading failures, triggered by an initially localized overload in power systems, and the critical slowing downs of ecosystems which can be driven towards extinction. In recent years, this general phenomenon has been investigated by framing localized and systemic failures in terms of perturbations that can alter the function of a system. We capitalize on this mathematical framework to review theoretical and computational approaches to characterize robustness and resilience of complex networks. We discuss recent approaches to mitigate the impact of perturbations in terms of designing robustness, identifying early-warning signals and adapting responses. In terms of applications, we compare the performance of the state-of-the-art dismantling techniques, highlighting their optimal range of applicability for practical problems, and provide a repository with ready-to-use scripts, a much-needed tool set.

Microscopic structural damage, such as lesions in neural systems or disruptions in urban transportation networks, can impair the dynamics crucial for systems' functionality, such as electrochemical signals or human flows, or any other type of information exchange, respectively, at larger topological scales. Damage is usually modeled by progressive removal of components or connections and, consequently, systems' robustness is assessed in terms of how fast their structure fragments into disconnected subsystems. Yet, this approach fails to capture how damage hinders the propagation of information across scales, since system function can be degraded even in absence of fragmentation—e.g., pathological yet structurally integrated human brain. Here, we probe the response to damage of dynamical processes on the top of complex networks, to study how such an information flow is affected. We find that removal of nodes central for network connectivity might have insignificant effects, challenging the traditional assumption that structural metrics alone are sufficient to gain insights about how complex systems operate. Using a damaging protocol explicitly accounting for flow dynamics, we analyze synthetic and empirical systems, from biological to infrastructural ones, and show that it is possible to drive the system towards functional fragmentation before full structural disintegration.

The governance of the political and economic world order builds on a complex architecture of international treaties at various geographical scales. In a historical phase of high institutional turbulence, assessing the stability of such architecture with respect to the unilateral defection of single countries and the breakdown of single treaties is important. We carry out this analysis on the whole global architecture and find that the countries with the highest disruption potential are mostly medium-small and micro countries. Political stability is highly dependent on many former colonial overseas territories that are today part of the global network of fiscal havens, as well as on emerging economies, mostly from South-East Asia. Economic stability depends on medium-sized European and African countries. Single global treaties have surprisingly less disruptive potential, with the major exception of the WTO. Our results suggest that the potential fragility of the world order seems to be more directly related to global inequality and fiscal injustice than commonly believed and that the legacy of the colonial world order is still strong in the current international relations scenario. In particular, vested interests related to tax avoidance seem to have a structural role in the political architecture of global governance.

After the leak of 11.5 million documents from the Panamanian corporation Mossack Fonseca, an intricate network of offshore business entities has been revealed. The emerging picture is that of legal entities, either individuals or companies, involved in offshore activities and transactions with several tax havens simultaneously which establish, indirectly, an effective network of countries acting on tax evasion. The analysis of this network quantitatively uncovers a strongly connected core (a rich-club) of countries whose indirect interactions, mediated by legal entities, form the skeleton for tax evasion worldwide. Intriguingly, the rich-club mainly consists of well-known tax havens such as British Virgin Islands and Hong Kong, and major global powers such as China, Russia, United Kingdom and United States of America. Our findings build a ground for better understanding phenomena where the erosion of public trust may spark emergent social dynamics, such as social conflicts and political polarization, that are driven by the complex interconnected structure of tax evaders in a globalized economy.

When a large number of similar entities interact among each other and with their environment at a low scale, unexpected outcomes at higher spatio-temporal scales might spontaneously arise. This nontrivial phenomenon, known as emergence, characterizes a broad range of distinct complex systems -- from physical to biological and social ones -- and is often related to collective behavior. It is ubiquitous, from non-living entities such as oscillators that under specific conditions synchronize, to living ones, such as birds flocking or fish schooling. Despite the ample phenomenological evidence of the existence of systems' emergent properties, central theoretical questions to the study of emergence remain still unanswered, such as the lack of a widely accepted, rigorous definition of the phenomenon or the identification of the essential physical conditions that favour emergence. We offer here a general overview of the phenomenon of emergence and sketch current and future challenges on the topic. Our short review also serves as an introduction to the Theme Issue "Emergent phenomena in complex physical and socio-technical systems: from cells to societies", where we provide a synthesis of the contents tackled in the Issue and outline how they relate to these challenges, spanning from current advances in our understanding on the origin of life to the large-scale propagation of infectious diseases.

Localized perturbations in a real-world network have the potential to trigger cascade failures at the whole system level, hindering its operations and functions. Standard approaches analytically tackling this problem are mostly based either on static descriptions, such as percolation, or on models where the failure evolves through first-neighbor connections, crucially failing to capture the nonlocal behavior typical of real cascades. We introduce a dynamical model that maps the failure propagation across the network to a self-avoiding random walk that, at each step, has a probability to perform nonlocal jumps toward operational systems' units. Despite the inherent non-Markovian nature of the process, we are able to characterize the critical behavior of the system out of equilibrium, as well as the stopping time distribution of the cascades. Our numerical experiments on synthetic and empirical biological and transportation networks are in excellent agreement with theoretical expectation, demonstrating the ability of our framework to quantify the vulnerability to nonlocal cascade failures of complex systems with interconnected structure.

For decades, from design theory to urban planning and management, from social sciences to urban environmental science, cities have been probed and analyzed from the partial perspective of single disciplines. The digital era, with its unprecedented data availability, is allowing for testing old theories and developing new ones, ultimately challenging relatively partial models. Our community has been in the last years providing more and more compelling evidence that cities are complex systems with emergent phenomena characterized by the collective behavior of their citizens who are themselves complex systems. However, more recently, it has also been shown that such multiscale complexity alone is not enough to describe some salient features of urban systems. Multilayer network modeling, accounting for both multiplexity of relationships and interdependencies among the city’s subsystems, is indeed providing a novel integrated framework to study urban backbones, their resilience to unexpected perturbations due to internal or external factors, and their human flows. In this paper, we first offer an overview of the transdisciplinary efforts made to cope with the three dimensions of complexity of the city: the complexity of the urban environment, the complexity of human cognition about the city, and the complexity of city planning. In particular, we discuss how the most recent findings, for example, relating the health and wellbeing of communities to urban structure and function, from traffic congestion to distinct types of pollution, can be better understood considering a city as a multiscale and multilayer complex system. The new challenges posed by the postpandemic scenario give to this perspective an unprecedented relevance, with the necessity to address issues of reconstruction of the social fabric, recovery from prolonged psychological, social and economic stress with the ensuing mental health and wellbeing issues, and repurposing of urban organization as a consequence of new emerging practices such as massive remote working. By rethinking cities as large-scale active matter systems far from equilibrium which consume energy, process information, and adapt to the environment, we argue that enhancing social engagement, for example, involving citizens in codesigning the city and its changes in this critical postpandemic phase, can trigger widespread adoption of good practices leading to emergent effects with collective benefits which can be directly measured.

From physics to engineering, biology and social science, natural and artificial systems are characterized by interconnected topologies whose features – e.g., heterogeneous connectivity, mesoscale organization, hierarchy – affect their robustness to external perturbations, such as targeted attacks to their units. Identifying the minimal set of units to attack to disintegrate a complex network, i.e. network dismantling, is a computationally challenging (NP-hard) problem which is usually attacked with heuristics. Here, we show that a machine trained to dismantle relatively small systems is able to identify higher-order topological patterns, allowing to disintegrate large-scale social, infrastructural and technological networks more efficiently than human-based heuristics. Remarkably, the machine assesses the probability that next attacks will disintegrate the system, providing a quantitative method to quantify systemic risk and detect early-warning signals of system’s collapse. This demonstrates that machine-assisted analysis can be effectively used for policy and decision-making to better quantify the fragility of complex systems and their response to shocks.

The spread of an infectious disease is well approximated by metapopulation networks connected by human mobility flow and upon which an epidemiological model is defined. In order to account for travel restrictions or cancellation we introduce a model with a parameter that explicitly indicates the ratio between the time scales of the intervening processes. We study the critical properties of the epidemic process and its dependence on such a parameter. We find that the critical threshold separating the absorbing state from the active state depends on the scale parameter and exhibits a critical behavior itself: a metacritical point – a critical value in the curve of critical points – reflected in the behavior of the attack rate measured for a wide range of empirical metapopulation systems. Our results have potential policy implications, since they establish a non-trivial critical behavior between temporal scales of reaction (epidemic spread) and diffusion (human mobility) processes.

Complex systems are large collections of entities that organize themselves into non-trivial structures, represented as networks. One of their key emergent properties is robustness against random failures or targeted attacks —i.e., the networks maintain their integrity under removal of nodes or links. Here, we introduce network entanglement to study network robustness through a multiscale lens, encoded by the time required for information diffusion through the system. Our measure’s foundation lies upon a recently developed statistical field theory for information dynamics within interconnected systems. We show that at the smallest temporal scales, the node-network entanglement reduces to degree, whereas at extremely large scales, it measures the direct role played by each node in keeping the network connected. At the meso-scale, entanglement plays a more important role, measuring the importance of nodes for the transport properties of the system. We use entanglement as a centrality measure capturing the role played by nodes in keeping the overall diversity of the information flow. As an application, we study the disintegration of empirical social, biological and transportation systems, showing that the nodes central for information dynamics are also responsible for keeping the network integrated.

Percolation is an emblematic model to assess the robustness of interconnected systems when some of their components are corrupted. It is usually investigated in simple scenarios, such as the removal of the system’s units in random order, or sequentially ordered by specific topological descriptors. However, in the vast majority of empirical applications, it is required to dismantle the network following more sophisticated protocols, for instance, by combining topological properties and non-topological node metadata. We propose a novel mathematical framework to fill this gap: networks are enriched with features and their nodes are removed according to the importance in the feature space. We consider features of different nature, from ones related to the network construction to ones related to dynamical processes such as epidemic spreading. Our framework not only provides a natural generalization of percolation but, more importantly, offers an accurate way to test the robustness of networks in realistic scenarios.

Multilayer systems are coupled networks characterized by different contexts (layers) of interaction and have gained much attention recently due to their suitability to describe a broad spectrum of empirical complex systems. They are very fragile to percolation and first-neighbor failure propagation, but little is known about how they respond to non-local disruptions, as it occurs in failures induced by flow redistribution, for example. Acknowledging that many socio-technical and biological systems sustain a flow of some physical quantity, such as energy or information, across the their components, it becomes crucial to understand when the flow redistribution can cause global cascades of failures in order to design robust systems, to increase their resilience or to learn how to efficiently dismantle them. In this paper we study the impact that different multiplex topological features have on the robustness of the system when subjected to non-local cascade propagation. We first numerically demonstrate that this dynamics has a critical value at which a small initial perturbation effectively dismantles the entire network, and that the transition appears abruptly. Then we identify that the excess of flow caused by a failure is, in general, more homogeneously distributed the networks in which the average distance between nodes is small. Using this information we find that aggregated versions of multiplex networks tend to overestimate robustness, even though to make the system more robust can be achieved by increasing the number of layers. Our predictions are confirmed by simulated cascading failures in a real multilayer system.

In this RISJ Factsheet, we assess the volume and patterns of toxic conversations on social media during the Covid-19 pandemic. We specifically analyse worldwide conversations on Twitter targeting the World Health Organization (WHO), a central actor during the pandemic. Our analysis contributes to the current research on the health of online debates amid the increasing role of social media as a critical entrance to information and mediator of public opinion building.

The blockchain technology promises to transform finance, money and even governments. However, analyses of blockchain applicability and robustness typically focus on isolated systems whose actors contribute mainly by running the consensus algorithm. Here, we highlight the importance of considering trustless platforms within the broader ecosystem that includes social and communication networks. As an example, we analyse the flash-crash observed on 21st June 2017 in the Ethereum platform and show that a major phenomenon of social coordination led to a catastrophic cascade of events across several interconnected systems. We propose the concept of “emergent centralisation” to describe situations where a single system becomes critically important for the functioning of the whole ecosystem, and argue that such situations are likely to become more and more frequent in interconnected socio-technical systems. We anticipate that the systemic approach we propose will have implications for future assessments of trustless systems and call for the attention of policy-makers on the fragility of our interconnected and rapidly changing world.

Publishing reproducible analyses is a long-standing and widespread challenge for the scientific community, funding bodies and publishers. Although a definitive solution is still elusive, the problem is recognized to affect all disciplines and lead to a critical system inefficiency. Here, we propose a blockchain-based approach to enhance scientific reproducibility, with a focus on life science studies and precision medicine. While the interest of encoding permanently into an immutable ledger all the study key information-including endpoints, data and metadata, protocols, analytical methods and all findings-has been already highlighted, here we apply the blockchain approach to solve the issue of rewarding time and expertise of scientists that commit to verify reproducibility. Our mechanism builds a trustless ecosystem of researchers, funding bodies and publishers cooperating to guarantee digital and permanent access to information and reproducible results. As a natural byproduct, a procedure to quantify scientists and institutions reputation for ranking purposes is obtained.

The coexistence of multiple types of interactions within social, technological and biological networks has moved the focus of the physics of complex systems towards a multiplex description of the interactions between their constituents. This novel approach has unveiled that the multiplex nature of complex systems has strong influence in the emergence of collective states and their critical properties. Here we address an important issue that is intrinsic to the coexistence of multiple means of interactions within a network: their competition. To this aim, we study a two-layer multiplex in which the activity of users can be localized in each of the layer or shared between them, favoring that neighboring nodes within a layer focus their activity on the same layer. This framework mimics the coexistence and competition of multiple communication channels, in a way that the prevalence of a particular communication platform emerges as a result of the localization of users activity in one single interaction layer. Our results indicate that there is a transition from localization (use of a preferred layer) to delocalization (combined usage of both layers) and that the prevalence of a particular layer (in the localized state) depends on their structural properties.

Assessing the navigability of interconnected networks (transporting information, people, or goods) under eventual random failures is of utmost importance to design and protect critical infrastructures. Random walks are a good proxy to determine this navigability, specifically the coverage time of random walks, which is a measure of the dynamical functionality of the network. Here, we introduce the theoretical tools required to describe random walks in interconnected networks accounting for structure and dynamics inherent to real systems. We develop an analytical approach for the covering time of random walks in interconnected networks and compare it with extensive Monte Carlo simulations. Generally speaking, interconnected networks are more resilient to random failures than their individual layers per se, and we are able to quantify this effect. As an application, which we illustrate by considering the public transport of London, we show how the efficiency in exploring the multiplex critically depends on layers’ topology, interconnection strengths, and walk strategy. Our findings are corroborated by data-driven simulations, where the empirical distribution of check-ins and checks-out is considered and passengers travel along fastest paths in a network affected by real disruptions. These findings are fundamental for further development of searching and navigability strategies in real interconnected systems.

Multiplex networks are receiving increasing interests because they allow to model relationships between networked agents on several layers simultaneously. In this letter, we extend well-known random walks to multiplexes and we introduce a new type of walk that can exist only in multiplexes. We derive exact expressions for vertex occupation time and the coverage. Finally, we show how the efficiency in exploring the multiplex critically depends on the underlying topology of layers, the weight of their inter-connections and the strategy adopted to walk.

We investigate flow dynamics in rivers characterized by basin areas and daily mean discharge spanning different orders of magnitude. We show that the delayed increments evaluated at time scales ranging from days to months can be opportunely rescaled to the same non-Gaussian probability density function. Such a scaling breaks up above a certain critical horizon, where a behavior typical of thermodynamic systems at the critical point emerges. We finally show that both the scaling behavior and the break up of the scaling are universal features of river flow dynamics.

The boundaries between physical and social networks have narrowed with the advent of the Internet and its pervasive platforms. This has given rise to a complex adaptive information ecosystem where individuals and machines compete for attention, leading to emergent collective phenomena. The flow of information in this ecosystem is often non-trivial and involves complex user strategies—from the forging or strategic amplification of manipulative content to large-scale coordinated behavior—that trigger misinformation cascades, echo-chamber reinforcement, and opinion polarization. We argue that statistical physics provides a suitable and necessary framework for analyzing the unfolding of these complex dynamics on socio-technological systems. This review systematically covers the foundational and applied aspects of this framework. The review is structured to first establish the theoretical foundation for analyzing these complex systems, examining both structural models of complex networks and physical models of social dynamics (e.g., epidemic and spin models). We then ground these concepts by describing the modern media ecosystem where these dynamics currently unfold, including a comparative analysis of platforms and the challenge of information disorders. The central sections proceed to apply this framework to two central phenomena: first, by analyzing the collective dynamics of information spreading, with a dedicated focus on the models, the main empirical insights, and the unique traits characterizing misinformation; and second, by reviewing current models of opinion dynamics, spanning discrete, continuous, and coevolutionary approaches. In summary, we review both empirical findings based on massive data analytics and theoretical advances, highlighting the valuable insights obtained from physics-based efforts to investigate these phenomena of high societal impact.

Cognitive agents, powered by Large Language Models (LLMs), possess advanced reasoning and communication capabilities that fundamentally distinguish them from non-cognitive particles, which rely solely on formal rules. While their ability to replicate human individual and social behaviors is still under scrutiny, the impact of their embedded “intelligence” on emergent behaviors remains poorly understood. Here, by comparing cognitive agents with classic particles, we investigate how LLM capabilities shape emergent phenomena in two tasks: function optimization and social organization emerging from the Schelling model of segregation. To this aim, we introduce LLM Agent Swarm Optimization (llmASO), where a swarm of interacting LLM agents acts as an optimizer. Our findings reveal that, while individual agents outperform particles in decision-making, their consensus tendencies and ability to exploit patterns can make them prone to premature convergence. Adjusting network topology can alleviate this effect, but typically at the cost of slower overall convergence compared to classical Particle Swarm Optimization (PSO). In contrast, in the Schelling model, we demonstrate that local interactions and homophilic mechanisms allow cognitive agents to generate distinct emergent behaviors, underscoring the importance of realistic communication architectures in complex social simulations. This work clarifies how LLM capabilities introduce new mechanisms for collective behavior and has implications for future applications of LLM agents in swarm robotics, social experiments, and complex decision-making tasks.

Reconstructing functional brain networks from functional Magnetic Resonance Imaging (fMRI) data typically relies on statistical pruning, where pairwise correlations between brain Regions of Interest (ROIs) are independently thresholded, ignoring potentially relevant collective co-activation patterns within sub-networks. Here we introduce a functional pruning approach that identifies which connections to retain based on their collective importance for distinguishing healthy from affected individuals, rather than on their individual statistical significance. We use geometric deep learning to learn network representations and an Explainable Artificial Intelligence (XAI) tool to identify the most discriminative sub-networks. Using fMRI data from healthy and Autism Spectrum Disorder (ASD) subjects, we build multilayer network representations from a multi-frequency decomposition of the signals and provide robust evidence that the machine-learned sub-systemic co-activation patterns significantly improve the identification of affected individuals. Our results demonstrate how functional pruning — which is based on collective, rather than individual, co-activation patterns — provides mechanistic insights that can be reliably used to characterize brain disorders, at variance with statistical pruning. Our approach is general and can be applied to find biomarkers for other brain diseases and, more broadly, to analyze complex systems where only the activity of individual units can be measured.

The path towards the emergence of life in our biosphere involved several key events allowing for the persistence, reproduction and evolution of molecular systems. All these processes took place in a given environmental context and required both molecular diversity and the right non-equilibrium conditions to sustain and favour complex self-sustaining molecular networks capable of evolving by natural selection. Life is a process that departs from non-life in several ways and cannot be reduced to standard chemical reactions. Moreover, achieving higher levels of complexity required the emergence of novelties. How did that happen? Here, we review different case studies associated with the early origins of life in terms of phase transitions and bifurcations, using symmetry breaking and percolation as two central components. We discuss simple models that allow for understanding key steps regarding life origins, such as molecular chirality, the transition to the first replicators and cooperators, the problem of error thresholds and information loss and the potential for ‘order for free’ as the basis for the emergence of life.

A broad class of systems, including ecological, epidemiological, and sociological ones, are characterized by populations of individuals assigned to specific categories, e.g., a chemical species, an opinion, or an epidemic state, that are modeled as compartments. Because of interactions and intrinsic dynamics, the system units are allowed to change category, leading to concentrations varying over time with complex behavior, typical of reaction-diffusion systems. While compartmental modeling provides a powerful framework for studying the dynamics of such populations and describe the spatiotemporal evolution of a system, it mostly relies on deterministic mean-field descriptions to deal with systems with many degrees of freedom. Here, we propose a method to alleviate some of the limitations of compartmental models by capitalizing on tools originating from quantum physics to systematically reduce multidimensional systems to an effective one-dimensional representation. Using this reduced system, we are able not only to investigate the mean-field dynamics and their critical behavior, but we can additionally study stochastic representations that capture fundamental features of the system. We demonstrate the validity of our formalism by studying the critical behavior of models widely adopted to study epidemic, ecological, and economic systems.

Complex systems are characterized by emergent patterns created by the nontrivial interplay between dynamical processes and the networks of interactions on which these processes unfold. Topological or dynamical descriptors alone are not enough to fully embrace this interplay in all its complexity, and many times one has to resort to dynamics-specific approaches that limit a comprehension of general principles. To address this challenge, we employ a metric—that we name Jacobian distance—which captures the spatiotemporal spreading of perturbations, enabling us to uncover the latent geometry inherent in network-driven processes. We compute the Jacobian distance for a broad set of nonlinear dynamical models on synthetic and real-world networks of high interest for applications from biological to ecological and social contexts. We show, analytically and computationally, that the process-driven latent geometry of a complex network is sensitive to both the specific features of the dynamics and the topological properties of the network. This translates into potential mismatches between the functional and the topological mesoscale organization, which we explain by means of the spectrum of the Jacobian matrix. Finally, we demonstrate that the Jacobian distance offers a clear advantage with respect to traditional methods when studying human brain networks. In particular, we show that it outperforms classical network communication models in explaining functional communities from structural data, therefore highlighting its potential in linking structure and function in the brain.

It has been argued that the historical nature of evolution makes it a highly path-dependent process. Under this view, the outcome of evolutionary dynamics could have resulted in organisms with different forms and functions. At the same time, there is ample evidence that convergence and constraints strongly limit the domain of the potential design principles that evolution can achieve. Are these limitations relevant in shaping the fabric of the possible? Here, we argue that fundamental constraints are associated with the logic of living matter. We illustrate this idea by considering the thermodynamic properties of living systems, the linear nature of molecular information, the cellular nature of the building blocks of life, multicellularity and development, the threshold nature of computations in cognitive systems, and the discrete nature of the architecture of ecosystems. In all these examples, we present available evidence and suggest potential avenues towards a well-defined theoretical formulation.

Complex network states are characterized by the interplay between system’s structure and dynamics. One way to represent such states is by means of network density matrices, whose von Neumann entropy characterizes the number of distinct microstates compatible with given topology and dynamical evolution. In this Letter, we propose a maximum entropy principle to characterize network states for systems with heterogeneous, generally correlated, connectivity patterns and non-trivial dynamics. We focus on three distinct coalescence processes, widely encountered in the analysis of empirical interconnected systems, and characterize their entropy and transitions between distinct dynamical regimes across distinct temporal scales. Our framework allows one to study the statistical physics of systems that aggregate, such as in transportation infrastructures serving the same geographic area, or correlate, such as inter-brain synchrony arising in organisms that socially interact, and active matter that swarm or synchronize.

Complex systems must respond to external perturbations and, at the same time, internally distribute information to coordinate their components. Although networked backbones help with the latter, they limit the components’ individual degrees of freedom and reduce their collective dynamical range. Here we show that real-world networks balance the loss of response diversity with gain in information flow. Encoding network states as density matrices, we demonstrate that such a trade-off mathematically resembles the thermodynamic efficiency characterized by heat and work in physical systems, providing a variational principle to macroscopically explain the sparsity and empirical scaling law observed in hundreds of real-world networks across multiple domains, both analytically and numerically. We show that the emergence of topological features such as modularity, small-worldness and heterogeneity agrees with maximizing the trade-off between information exchange and response diversity from middle to large temporal scales. Our results suggest that the emergence of some of the most prevalent topological features of real-world networks might have a thermodynamic origin.

The information implicitly represented in the state of physical systems allows for their analysis using analytical techniques from statistical mechanics and information theory. This approach has been successfully applied to complex networks, including biophysical systems such as virus-host protein-protein interactions and whole-brain models in health and disease, drawing inspiration from quantum statistical physics. Here we propose a general mathematical framework for modeling information dynamics on complex networks, where the internal node states are vector valued, allowing each node to carry multiple types of information. This setup is relevant for various biophysical and sociotechnological models of complex systems, ranging from viral dynamics on networks to models of opinion dynamics and social contagion. Instead of focusing on node-node interactions, we shift our attention to the flow of information between network configurations. We uncover fundamental differences between widely used spin models on networks, such as voter and kinetic dynamics, which cannot be detected through classical node-based analysis. We illustrate the mathematical framework further through an exemplary application to epidemic spreading on a low-dimensional network. Our model provides an opportunity to adapt powerful analytical methods from quantum many-body systems to study the interplay between structure and dynamics in interconnected systems.

The network density matrix formalism allows for describing the dynamics of information on top of complex structures and it has been successfully used to analyze, e.g., a system's robustness, perturbations, coarse-graining multilayer networks, characterization of emergent network states, and performing multiscale analysis. However, this framework is usually limited to diffusion dynamics on undirected networks. Here, to overcome some limitations, we propose an approach to derive density matrices based on dynamical systems and information theory, which allows for encapsulating a much wider range of linear and nonlinear dynamics and richer classes of structure, such as directed and signed ones. We use our framework to study the response to local stochastic perturbations of synthetic and empirical networks, including neural systems consisting of excitatory and inhibitory links and gene-regulatory interactions. Our findings demonstrate that topological complexity does not necessarily lead to functional diversity, i.e., the complex and heterogeneous response to stimuli or perturbations. Instead, functional diversity is a genuine emergent property which cannot be deduced from the knowledge of topological features such as heterogeneity, modularity, the presence of asymmetries, and dynamical properties of a system.

Recurrent networks are a special class of artificial neural systems that use their internal states to perform computing tasks for machine learning. One of its state-of-the-art developments, i.e. reservoir computing (RC), uses the internal structure -- usually a static network with random structure -- to map an input signal into a nonlinear dynamical system defined in a higher dimensional space. Reservoirs are characterized by nonlinear interactions among their units and their ability to store information through recurrent loops, allowing to train artificial systems to learn task-specific dynamics. However, it is fundamentally unknown how the random topology of the reservoir affects the learning performance. Here, we fill this gap by considering a battery of synthetic networks -- characterized by different topological features -- and 45 empirical connectomes -- sampled from brain regions of organisms belonging to 8 different species -- to build the reservoir and testing the learning performance against a prediction task with a variety of complex input signals. We find nontrivial correlations between RC performances and both the number of nodes and rank of the covariance matrix of activation states, with performance depending on the nature -- stochastic or deterministic -- of input signals. Remarkably, the modularity and the link density of the reservoir are found to affect RC performances: these results cannot be predicted by models only accounting for simple topological features of the reservoir. Overall, our findings highlight that the complex topological features characterizing biophysical computing systems such as connectomes can be used to design efficient bio-inspired artificial neural networks.

Online platforms play a relevant role in the creation and diffusion of false or misleading news. Concerningly, the COVID-19 pandemic is shaping a communication network which reflects the emergence of collective attention towards a topic that rapidly gained universal interest. Here, we characterize the dynamics of this network on Twitter, analysing how unreliable content distributes among its users. We find that a minority of accounts is responsible for the majority of the misinformation circulating online, and identify two categories of users: a few active ones, playing the role of ‘creators’, and a majority playing the role of ‘consumers’. The relative proportion of these groups (approx. 14% creators—86% consumers) appears stable over time: consumers are mostly exposed to the opinions of a vocal minority of creators (which are the origin of 82% of fake content in our data), that could be mistakenly understood as representative of the majority of users. The corresponding pressure from a perceived majority is identified as a potential driver of the ongoing COVID-19 infodemic.

When a large number of similar entities interact among each other and with their environment at a low scale, unexpected outcomes at higher spatio-temporal scales might spontaneously arise. This nontrivial phenomenon, known as emergence, characterizes a broad range of distinct complex systems -- from physical to biological and social ones -- and is often related to collective behavior. It is ubiquitous, from non-living entities such as oscillators that under specific conditions synchronize, to living ones, such as birds flocking or fish schooling. Despite the ample phenomenological evidence of the existence of systems' emergent properties, central theoretical questions to the study of emergence remain still unanswered, such as the lack of a widely accepted, rigorous definition of the phenomenon or the identification of the essential physical conditions that favour emergence. We offer here a general overview of the phenomenon of emergence and sketch current and future challenges on the topic. Our short review also serves as an introduction to the Theme Issue "Emergent phenomena in complex physical and socio-technical systems: from cells to societies", where we provide a synthesis of the contents tackled in the Issue and outline how they relate to these challenges, spanning from current advances in our understanding on the origin of life to the large-scale propagation of infectious diseases.

During the COVID-19 epidemic, draconian countermeasures forbidding nonessential human activities have been adopted in several countries worldwide, providing an unprecedented setup for testing and quantifying the current impact of humankind on climate and for driving potential sustainability policies in the postpandemic era from a perspective of complex systems. In this study, we consider heterogeneous sources of environmental and human activity observables, considered as components of a complex socioenvironmental system, and apply information theory, network science, and Bayesian inference to analyze their structural relations and nonlinear dynamics between January 2019 and August 2020 in northern Italy, i.e., before, during, and after the national lockdown. The topological structure of a complex system strongly impacts its collective behavior; therefore, mapping this structure is essential to fully understand the functions of the system as a whole and its fragility to unexpected disruptions or shocks. To this aim, we unravel the causal relationships between the 16 environmental conditions and human activity variables, mapping the backbone of the complex interplay between intervening physical observables—such as NO2 emissions, energy consumption, intervening climate variables, and different flavors of human mobility flows—to a causal network model. To identify a tipping point during the period of observation, denoting the presence of a regime shift between distinct network states (i.e., before and during the shock), we introduce a novel information-theoretic method based on statistical divergence widely used in statistical physics. We find that despite a measurable decrease in NO2 concentration, due to an overall decrease in human activities, locking down a region as a climate change mitigation is an insufficient remedy to reduce emissions. Our results provide a functional characterization of socioenvironmental interdependent systems, and our analytical framework can be used, more generally, to characterize environmental changes and their interdependencies using statistical physics.

Complex biological systems consist of large numbers of interconnected units, characterized by emergent properties such as collective computation. In spite of all the progress in the last decade, we still lack a deep understanding of how these properties arise from the coupling between the structure and dynamics. Here, we introduce the multiscale emergent functional state, which can be represented as a network where links encode the flow exchange between the nodes, calculated using diffusion processes on top of the network. We analyze the emergent functional state to study the distribution of the flow among components of 92 fungal networks, identifying their functional modules at different scales and, more importantly, demonstrating the importance of functional modules for information content of networks, quantified in terms of network spectral entropy. Our results suggest that the topological complexity of fungal networks guarantees the existence of functional modules at different scales keeping the information entropy, and functional diversity, high.

For decades, from design theory to urban planning and management, from social sciences to urban environmental science, cities have been probed and analyzed from the partial perspective of single disciplines. The digital era, with its unprecedented data availability, is allowing for testing old theories and developing new ones, ultimately challenging relatively partial models. Our community has been in the last years providing more and more compelling evidence that cities are complex systems with emergent phenomena characterized by the collective behavior of their citizens who are themselves complex systems. However, more recently, it has also been shown that such multiscale complexity alone is not enough to describe some salient features of urban systems. Multilayer network modeling, accounting for both multiplexity of relationships and interdependencies among the city’s subsystems, is indeed providing a novel integrated framework to study urban backbones, their resilience to unexpected perturbations due to internal or external factors, and their human flows. In this paper, we first offer an overview of the transdisciplinary efforts made to cope with the three dimensions of complexity of the city: the complexity of the urban environment, the complexity of human cognition about the city, and the complexity of city planning. In particular, we discuss how the most recent findings, for example, relating the health and wellbeing of communities to urban structure and function, from traffic congestion to distinct types of pollution, can be better understood considering a city as a multiscale and multilayer complex system. The new challenges posed by the postpandemic scenario give to this perspective an unprecedented relevance, with the necessity to address issues of reconstruction of the social fabric, recovery from prolonged psychological, social and economic stress with the ensuing mental health and wellbeing issues, and repurposing of urban organization as a consequence of new emerging practices such as massive remote working. By rethinking cities as large-scale active matter systems far from equilibrium which consume energy, process information, and adapt to the environment, we argue that enhancing social engagement, for example, involving citizens in codesigning the city and its changes in this critical postpandemic phase, can trigger widespread adoption of good practices leading to emergent effects with collective benefits which can be directly measured.

Revealing the structural features of a complex system from the observed collective dynamics is a fundamental problem in network science. To compute the various topological descriptors commonly used to characterize the structure of a complex system (e.g., the degree, the clustering coefficient, etc.), it is usually necessary to completely reconstruct the network of relations between the subsystems. Several methods are available to detect the existence of interactions between the nodes of a network. By observing some physical quantities through time, the structural relationships are inferred using various discriminating statistics (e.g., correlations, mutual information, etc.). In this setting, the uncertainty about the existence of the edges is reflected in the uncertainty about the topological descriptors. In this study, we propose a methodological framework to evaluate this uncertainty, replacing the topological descriptors, even at the level of a single node, with appropriate probability distributions, eluding the reconstruction phase. Our theoretical framework agrees with the numerical experiments performed on a large set of synthetic and real-world networks. Our results provide a grounded framework for the analysis and the interpretation of widely used topological descriptors, such as degree centrality, clustering, and clusters, in scenarios in which the existence of network connectivity is statistically inferred or when the probabilities of existence pij of the edges are known. To this purpose, we also provide a simple and mathematically grounded process to transform the discriminating statistics into the probabilities pij.

The constituents of a complex system exchange information to function properly. Their signaling dynamics often leads to the appearance of emergent phenomena, such as phase transitions and collective behaviors. While information exchange has been widely modeled by means of distinct spreading processes—such as continuous-time diffusion, random walks, synchronization and consensus—on top of complex networks, a unified and physically grounded framework to study information dynamics and gain insights about the macroscopic effects of microscopic interactions is still eluding us. In this paper, we present this framework in terms of a statistical field theory of information dynamics, unifying a range of dynamical processes governing the evolution of information on top of static or time-varying structures. We show that information operators form a meaningful statistical ensemble and their superposition defines a density matrix that can be used for the analysis of complex dynamics. As a direct application, we show that the von Neumann entropy of the ensemble can be a measure of the functional diversity of complex systems, defined in terms of the functional differentiation of higher-order interactions among their components. Our results suggest that modularity and hierarchy, two key features of empirical complex systems—from the human brain to social and urban networks—play a key role to guarantee functional diversity and, consequently, are favored.

In the era of social media, every day billions of individuals produce content in socio-technical systems resulting in a deluge of information. However, human attention is a limited resource and it is increasingly challenging to consume the most suitable content for one's interests. In fact, the complex interplay between individual and social activities in social systems overwhelmed by information results in bursty activity of collective attention which are still poorly understood. Here, we tackle this challenge by analyzing the online activity of millions of users in a popular microblogging platform during exceptional events, from NBA Finals to the elections of Pope Francis and the discovery of gravitational waves. We observe extreme fluctuations in collective attention that we are able to characterize and explain by considering the co-occurrence of two fundamental factors: the heterogeneity of social interactions and the preferential attention towards influential users. Our findings demonstrate how combining simple mechanisms provides a route towards complex social phenomena.

In collective decision-making, a group of independent experts propose individual choices to reach a common decision. This is the case of competitive events such as Olympics, international Prizes or grant evaluation, where groups of experts evaluate individual performances to assign resources, e.g. scores, recognitions, or funding. However, there are systems where evaluating individual’s performance is difficult: in those cases, other factors play a relevant role, leading to unexpected emergent phenomena from micro-scale interactions. The Nobel assignment procedure, rooted on recommendations, is one of these systems. Here we unveil its network, reconstructed from official data and metadata about nominators, nominees and awardees between 1901 and 1965, consisting of almost 12,000 individuals and 17,000 nominations. We quantify the role of homophily, academic reputation of nominators and their prestige neighborhood, showing that nominees endorsed by central actors – who are part of the system’s core because of their prestigious reputation – are more likely to become laureate within a finite time scale than nominees endorsed by nominators in the periphery of the network. We propose a mechanistic model which reproduces all the salient observations and allows to design possible countermeasures to mitigate observed effects..

Collective phenomena emerge from the interaction of natural or artificial units with a complex organization. The interplay between structural patterns and dynamics might induce functional clusters that, in general, are different from topological ones. In biological systems, like the human brain, the overall functionality is often favored by the interplay between connectivity and synchronization dynamics, with functional clusters that do not coincide with anatomical modules in most cases. In social, sociotechnical, and engineering systems, the quest for consensus favors the emergence of clusters. Despite the unquestionable evidence for mesoscale organization of many complex systems and the heterogeneity of their interconnectivity, a way to predict and identify the emergence of functional modules in collective phenomena continues to elude us. Here, we propose an approach based on random walk dynamics to define the diffusion distance between any pair of units in a networked system. Such a metric allows us to exploit the underlying diffusion geometry to provide a unifying framework for the intimate relationship between metastable synchronization, consensus, and random search dynamics in complex networks, pinpointing the functional mesoscale organization of synthetic and biological systems.

The coexistence of multiple types of interactions within social, technological and biological networks has moved the focus of the physics of complex systems towards a multiplex description of the interactions between their constituents. This novel approach has unveiled that the multiplex nature of complex systems has strong influence in the emergence of collective states and their critical properties. Here we address an important issue that is intrinsic to the coexistence of multiple means of interactions within a network: their competition. To this aim, we study a two-layer multiplex in which the activity of users can be localized in each of the layer or shared between them, favoring that neighboring nodes within a layer focus their activity on the same layer. This framework mimics the coexistence and competition of multiple communication channels, in a way that the prevalence of a particular communication platform emerges as a result of the localization of users activity in one single interaction layer. Our results indicate that there is a transition from localization (use of a preferred layer) to delocalization (combined usage of both layers) and that the prevalence of a particular layer (in the localized state) depends on their structural properties.

Nowadays, millions of people interact on a daily basis on online social media like Facebook and Twitter, where they share and discuss information about a wide variety of topics. In this paper, we focus on a specific online social network, Twitter, and we analyze multiple datasets each one consisting of individuals' online activity before, during and after an exceptional event in terms of volume of the communications registered. We consider important events that occurred in different arenas that range from policy to culture or science. For each dataset, the users' online activities are modeled by a multilayer network in which each layer conveys a different kind of interaction, specifically: retweeting, mentioning and replying. This representation allows us to unveil that these distinct types of interaction produce networks with different statistical properties, in particular concerning the degree distribution and the clustering structure. These results suggests that models of online activity cannot discard the information carried by this multilayer representation of the system, and should account for the different processes generated by the different kinds of interactions. Secondly, our analysis unveils the presence of statistical regularities among the different events, suggesting that the non-trivial topological patterns that we observe may represent universal features of the social dynamics on online social networks during exceptional events.